“Ozempic is about to be old news,” my colleague Yasmin Tayag wrote in 2023, just before an even more powerful obesity drug, tirzepatide, then best known as Mounjaro, was approved. Well, two years later, Mounjaro is becoming old news, too. A whole slew of next-generation obesity drugs are on the horizon, some already advanced enough in clinical trials to be looking as good as—if not better than—those already on the market.
Few things in life are both cheaper and better, but for a long time, this was true of the chicken thigh. Its superiority was passed like a shibboleth among food connoisseurs: Thighs are juicier, tastier, are almost half the price—preferable in just about every way to the boneless, skinless, flavorless breasts that reign supreme in America.
Well, the secret’s out.
Last year, in July, Reine Protacio’s experiments suddenly stopped working. Every scientist encounters baffling results from time to time; you chalk it up to error, repeat the experiment, and hope for the best. But in this case, the problem didn’t resolve and in fact spread to other members of the lab: Their yeast, which normally multiples with such intense fecundity that 500 colonies might bloom across a single laboratory dish, had become stunted.
Tami McGraw used to be so allergic to red meat that even fumes from cooking might send her into anaphylactic shock. She couldn’t fry sausages for her family. She couldn’t go to cookouts with friends. Once, she passed out driving home with her son after accidentally inhaling fumes while volunteering at the school cafeteria. “That’s the closest I came to dying,” she told me. Every whiff of sizzling meat, every journey out of the house came spring-loaded with danger.
Updated at 2:49 p.m. on August 15, 2024
By the time Lisa started breaking open her Mounjaro pens with pliers, she had run out of other ideas. She was 300 pounds. She had already tried bariatric surgery. (It had limited success.) She had tried getting her insurance company to cover Mounjaro. (It stopped after a month.) She had tried a cheaper copycat version from a compounding pharmacy. (It didn’t work as well, and she worried about what she was actually getting.
Recently, a man visiting his parents’ newly renovated home recognized an eerily familiar white curve in their tile floor. To the man, a dentist, it looked just like a jawbone. He could even count the teeth—one, two, three, four, five, at least. They seemed much like the ones he stares at all day at work.
The jawbone appeared at once very humanlike and very old, and the dentist took his suspicions to Reddit. Could it be that his parents’ floor tile contains a rare human fossil? Quite possibly.
When Steve Edsel was a boy, his adoptive parents kept a scrapbook of newspaper clippings in their bedroom closet. He would ask for it sometimes, poring over the headlines about his birth. Headlines like this: “Mother Deserts Son, Flees From Hospital,” Winston-Salem Journal, December 30, 1973.
The mother in question was 14 years old, “5 feet 6 with reddish brown hair,” and she had come to the hospital early one morning with her own parents. They gave names that all turned out to be fake.
When scientists first created the class of drugs that includes Ozempic, they told a tidy story about how the medications would work: The gut releases a hormone called GLP-1 that signals you’re full, so a drug that mimics GLP-1 could do the exact same thing, helping people eat less and lose weight.
The rest, as they say, is history.
The naked human is a vulnerable creature. Lacking the fur of our mammalian ancestors and relatives, we have bare skin that offers little defense against the sun’s brutal rays or wind’s biting chill. So instead, we have had to invent a technology to replace our long-lost fur: “portable thermal protection,” as the archaeologist Ian Gilligan calls it or, more simply, clothing.Without clothing, humans would never have reached all seven continents.
When Victoria Gray was still a baby, she started howling so inconsolably during a bath that she was rushed to the emergency room. The diagnosis was sickle-cell disease, a genetic condition that causes bouts of excruciating pain—“worse than a broken leg, worse than childbirth,” one doctor told me. Like lightning crackling in her body is how Gray, now 38, has described the pain.
Cyprus is home to 1 million or so free-roaming cats that wander its streets, parks, and even luxury resorts. They are about as numerous as people. So when a deadly cat outbreak began sweeping across the Mediterranean island this year, the humans quickly noticed something was terribly wrong.Stray and feral cats died by the thousands. Pet cats died, too.
You wake up with a stuffy nose, so you head to the pharmacy, where a plethora of options awaits in the cold-and-flu aisle. Ah, how lucky you are to live in 21st-century America. There’s Sudafed PE, which promises “maximum-strength sinus pressure and nasal congestion relief.” Sounds great.
Since Omicron swept across the globe in 2021, the evolution of SARS-CoV-2 has moved at a slower and more predictable pace. New variants of interest have come and gone, but none have matched Omicron’s 30-odd mutations or its ferocious growth. Then, about two weeks ago, a variant descended from BA.2 popped up with 34 mutations in its spike protein—a leap in viral evolution that sure looked a lot like Omicron.
Two summers ago, a patient looking out his Belgian-hospital window spied in a tree an odd, abandoned magpie nest of plastic and wire. He had, by coincidence, just read a newspaper article about a Dutch biologist who studies bird nests built of trash. So he dashed off an email, and that Dutch biologist, Auke-Florian Hiemstra, was soon in the hospital courtyard, climbing aboard a cherry picker to see the nest up close.
Statins, one of the most extensively studied drugs on the planet, taken by tens of millions of Americans alone, have long had a perplexing side effect. Many patients—some 5 percent in clinical trials, and up to 30 percent in observational studies—experience sore and achy muscles, especially in the upper arms and legs.
While her wife was pregnant with their son, Aimee MacDonald took an unusual step of preparing her own body for the baby’s arrival. First she began taking hormones, and then for six weeks straight, she pumped her breasts day and night every two to three hours. This process tricked her body into a pregnant and then postpartum state so she could make breast milk.
Baby names just aren’t what they used to be. You can see it these days in all the little Blakes and Emersons and Phoenixes and Robins—and if you can’t immediately tell whether I’m talking about boy or girl names, then ah, yes, that’s exactly it. When it comes to baby naming, we’re at peak androgyny.
Winter is coming. Again. For the past two years, colder temperatures have brought seasonal COVID upticks, which turned into massive waves when ill-timed new variants emerged. In Western Europe, the first part of that story certainly seems to be playing out again. Cases and hospitalizations started going up last month. No new variant has become dominant yet, but experts are monitoring a pair of potentially troubling viral offshoots called BQ.1 and XBB.
When is the pandemic “over”? In the early days of 2020, we envisioned it ending with the novel coronavirus going away entirely. When this became impossible, we hoped instead for elimination: If enough people got vaccinated, herd immunity might largely stop the virus from spreading.
At the heart of history’s most successful eradication campaign is a mystery. The smallpox vaccine—now also being deployed against monkeypox—contains a live virus that confers immunity against multiple poxviruses. But it is not smallpox or a weakened version thereof. Nor is it monkeypox. Nor is it cowpox, as suggested by the vaccine’s famous origin story involving pus taken from an infected milkmaid to immunize an 8-year-old boy.
To tell the story of how a purported cow tooth dug up in the Caribbean might corroborate the mythical origin of wild horses off the coast of Maryland and Virginia, let us begin, naturally, with a children’s book, Misty of Chincoteague.If you know, you know—horse girls, I’m looking at you. For everyone else: This beloved 1947 children’s novel tells the story of Misty the pony, born on the beaches of an uninhabited barrier island.
When Michelle Stokes noticed a necrotic wound on her cat, Jellyfish, last July, she and her husband had to call about 50 vets before finding one that could squeeze them in.The local emergency animal hospital was so backed up that it said the wound—serious but not yet life-threatening—wasn’t really an emergency. Jellyfish didn’t have a regular vet, because Stokes and her husband had just moved to the Cleveland area.
The “abortion pill” is a bit of a misnomer. Known formally as medical or medication abortion, it is really two separate drugs—mifepristone, which stops the pregnancy from progressing, followed by misoprostol, which triggers uterus contractions—that together mimic what happens in a miscarriage. And so, in the early days of at-home medication abortion in the 1990s in the U.K.
Nearly five years before an unusual cluster of monkeypox cases in the U.K. alarmed the world, doctors were dealing with an unusual cluster of monkeypox in another unexpected country: Nigeria. The virus is endemic to Central Africa, but Nigeria, far to the west, had not recorded a case of monkeypox since 1978. When an 11-year-old boy showed up with skin lesions in September 2017, doctors first suspected chickenpox. But no, tests pointed to the much more unusual monkeypox.
Last October, a young girl with severe and unusual liver failure was admitted to a hospital in Birmingham, Alabama. Her symptoms were typical: skin and eyes yellow with jaundice, markers of liver damage off the charts. But she tested negative for all the usual suspects behind liver disease. Her only positive test was, surprisingly, for adenovirus—a common virus best known for causing mild colds, pink eye, or stomach flu.
In September 1957—two years after church bells rang in celebration of the new polio vaccine, two years after people rejoiced in the streets, two years after Americans began lining up for their shots—the proportion of children fully vaccinated against polio remained at about 50 percent.Supply was not the problem.
It is common knowledge that COVID risk goes up with age, but how steeply it rises is still astounding to see after two years of living and dying with this coronavirus. Compared with someone in their 20s, a person over 65 years old is not slightly more likely to die of COVID but at least 65 times more likely to die of COVID. Over age 75, they become 140 times more likely to die. Over age 85, they are 340 times more likely to die.
To understand how the coronavirus keeps evolving into surprising new variants with new mutations, it helps to have some context: The virus’s genome is 30,000 letters long, which means that the number of possible mutation combinations is mind-bogglingly huge. As Jesse Bloom, a virologist at the Fred Hutchinson Cancer Research Center, told me, that number far, far exceeds the number of atoms in the known universe.
When Delta swept across the United States last year, the extremely transmissible and deadlier variant threw us into pandemic limbo. The virus remained a danger mostly to unvaccinated people, but they largely wanted to move on. Vaccinated people also largely wanted to move on. The virus did not want to move on. So we got stuck in a deadly rut, and more Americans died of COVID-19 in 2021 than in 2020.
The heaviest drinkers in the animal kingdom are punier than you might expect. Elephants, for example, are massive, but they are relative lightweights—they lack a gene for alcohol metabolism. Humans actually rank pretty highly, thanks to our ancestors’ propensity for picking fermented fruit off the ground. But to find the real champs, you have to think smaller.Think hoarder.Think hamster.